New Agent for Biliary Tract Cancer Approved

Source link : https://www.newshealth.biz/health-news/new-agent-for-biliary-tract-cancer-approved/ The U.S. Food and Drug Administration (FDA) has approved zanidatamab (Ziihera, Jazz Pharmaceuticals, Inc.) as monotherapy for previously treated, unresectable or metastatic HER2-positive biliary tract cancer (BTC). This approval makes the…

Which Breast Cancer Patients Can Skip Postop Radiotherapy?

Source link : https://www.newshealth.biz/health-news/which-breast-cancer-patients-can-skip-postop-radiotherapy/ TOPLINE: The Profile for the Omission of Local Adjuvant Radiation (POLAR) biomarker, a 16-gene molecular signature, can help predict locoregional recurrence in patients with ER-positive early breast cancer following breast-conserving surgery…

FDA Approves Zanidatamab for Biliary Tract Cancer

Source link : https://www.newshealth.biz/health-news/fda-approves-zanidatamab-for-biliary-tract-cancer/ The FDA on Wednesday granted accelerated approval to zanidatamab (Ziihera), a bispecific antibody, for pretreated HER2-positive biliary tract cancer. Approval stipulates use in unresectable or metastatic cases, with HER2 positivity defined…

Diet’s Role in Parkinson’s Disease

Source link : https://www.newshealth.biz/health-news/diets-role-in-parkinsons-disease/ Interest is growing in the role of nutrition as means of slowing, or even preventing, neurodegeneration in patients with Parkinson’s disease (PD). For 15 years, John Duda, MD, national director of…

Novel Therapy Reduced Liver Fat, Improved Fibrosis in MASH

Source link : https://www.newshealth.biz/health-news/novel-therapy-reduced-liver-fat-improved-fibrosis-in-mash/ Patients with biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis who received a novel small molecule thyroid hormone receptor agonist achieved statistically significant reductions in liver fat, the phase IIb randomized VOYAGE…

Policy Experts Split on Dr. Oz Nomination to Lead CMS

Source link : https://www.newshealth.biz/health-news/policy-experts-split-on-dr-oz-nomination-to-lead-cms/ President-elect Donald Trump’s nomination of cardiothoracic surgeon and former talk show host Mehmet Oz, MD, to serve as Centers for Medicare & Medicaid Services (CMS) administrator has divided policy experts, with…

US Alcohol-Related Deaths Double in Two Decades

Source link : https://www.newshealth.biz/health-news/us-alcohol-related-deaths-double-in-two-decades/ TOPLINE: US alcohol-related mortality rates increased from 10.7 to 21.6 per 100,000 between 1999 and 2020, with the largest rise of 3.8-fold observed in adults aged 25-34 years. Women experienced a…

Deprescribe Low-Value Meds to Reduce Polypharmacy Harms

Source link : https://www.newshealth.biz/health-news/deprescribe-low-value-meds-to-reduce-polypharmacy-harms/ VANCOUVER, British Columbia — While polypharmacy is inevitable for patients with multiple chronic diseases, not all medications improve patient-oriented outcomes, members of the Patients, Experience, Evidence, Research (PEER) team, a group…

Canadian Survey Reveals Sexual Harassment in Medicine

Source link : https://www.newshealth.biz/health-news/canadian-survey-reveals-sexual-harassment-in-medicine/ In a new Medscape survey, nearly 1 in 10 Canadian physicians said they’ve personally experienced sexual abuse, harassment, or misconduct at their medical workplace during the past 3 years. Similarly, 9%…

Shoulder Pain Pointers for Primary Care

Source link : https://www.newshealth.biz/health-news/shoulder-pain-pointers-for-primary-care/ The causes of shoulder pain may be as common as a traumatic injury or as rare as a systemic inflammatory condition, according to the American Academy of Orthopaedic Surgeons. The combination…

How to Stop Bone Loss After Denosumab? No Easy Answers

Source link : https://www.newshealth.biz/health-news/how-to-stop-bone-loss-after-denosumab-no-easy-answers/ Patients who discontinue treatment with the osteoporosis drug denosumab, despite transitioning to zoledronate, show significant losses in lumbar spine bone mineral density (BMD) within a year, according to the latest findings…

Denosumab Raises Hypocalcemia Risk in Chronic Kidney Disease

Source link : https://www.newshealth.biz/health-news/denosumab-raises-hypocalcemia-risk-in-chronic-kidney-disease/ TOPLINE: Denosumab treatment for osteoporosis raises the risk for hypocalcemia, which worsens with advancing stages of chronic kidney disease (CKD), in those with CKD–Mineral and Bone Disorder (CKD-MBD) and in those…

Vagus Nerve Stimulation Proves Effective in Refractory RA

Source link : https://www.newshealth.biz/health-news/vagus-nerve-stimulation-proves-effective-in-refractory-ra/ WASHINGTON — An implantable vagus nerve stimulation (VNS) device effectively treats moderate to severe rheumatoid arthritis (RA) in patients who had previously failed at least one biologic or targeted synthetic disease-modifying…

When Appendicitis Recurs: Two Case Studies

Source link : https://www.newshealth.biz/health-news/when-appendicitis-recurs-two-case-studies/ Stump appendicitis is a rare complication that occurs when the residual appendix becomes inflamed after an appendectomy. It is estimated to occur in between 0.002% and 0.15% of cases, although it…

Checkpoint Inhibitors Seem Safe in Autoimmune Disease

Source link : https://www.newshealth.biz/health-news/checkpoint-inhibitors-seem-safe-in-autoimmune-disease/ WASHINGTON — Immune checkpoint inhibitor (ICI) therapy does not increase mortality in people with preexisting autoimmune diseases, new research has found. Results from a large database analysis of patients with and…

Depression Affects Remission in Patients With RA or PsA

Source link : https://www.newshealth.biz/health-news/depression-affects-remission-in-patients-with-ra-or-psa/ TOPLINE: Depression is associated with lower odds of achieving remission in patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) over 2 years of follow-up. METHODOLOGY: Researchers analyzed data from two…

Elevated Stroke Risk Following NAION

Source link : https://www.newshealth.biz/health-news/elevated-stroke-risk-following-naion/ Nonarteritic anterior ischemic optic neuropathy (NAION) is significantly associated with persistently elevated risk for stroke, independent of typical cardiovascular risk factors, a large multinational cohort study showed. Stroke risk was three…

Ultraprocessed Foods Linked to Faster Biological Aging

Source link : https://www.newshealth.biz/health-news/ultraprocessed-foods-linked-to-faster-biological-aging/ TOPLINE: Consumption of ultraprocessed foods (UPFs), such as carbonated drinks, processed meats, and sweet or savory packaged snacks, is associated with accelerated biological aging, as measured by 36 blood-based biomarkers, and…

Now a Win for Nerve Stimulation in Rheumatoid Arthritis

Source link : https://www.newshealth.biz/health-news/now-a-win-for-nerve-stimulation-in-rheumatoid-arthritis/ WASHINGTON — A small implant delivering electrical stimulation to the vagus nerve outperformed a sham treatment in relieving rheumatoid arthritis (RA) symptoms among patients who failed at least one biologic or…

Laryngeal Dystonia Symptoms Improve With Novel Treatment

Source link : https://www.newshealth.biz/health-news/laryngeal-dystonia-symptoms-improve-with-novel-treatment/ Sodium oxybate provided temporary relief for laryngeal dystonia patients who were alcohol-responsive. The neurologic disorder causes laryngeal muscle spasms, leading to a chronically strained voice. Several public figures, including Robert F….

For AF, LAA Rivals Anticoagulants After Ablation

Source link : https://www.newshealth.biz/health-news/for-af-laa-rivals-anticoagulants-after-ablation/ A left atrial appendage (LAA) closure device provides long-term thromboembolic protection that is equivalent to direct oral anticoagulants after ablation for atrial fibrillation (AF), along with a lower risk of bleeding,…

Postpartum Depression Rose Significantly Over Past Decade

Source link : https://www.newshealth.biz/health-news/postpartum-depression-rose-significantly-over-past-decade/ Diagnoses of postpartum depression (PPD) increased significantly across all racial and ethnic groups and prepregnancy body mass index (BMI) categories over the past decade, according to a California-based cross-sectional study. An…

Eliminate Clozapine REMS, FDA Panels Say

Source link : https://www.newshealth.biz/health-news/eliminate-clozapine-rems-fda-panels-say/ Two US Food and Drug Administration (FDA) advisory panels are urging the agency to eliminate the risk management program for the antipsychotic drug clozapine, saying that restrictions are limiting access to…

GLP-1 Use Prior to Surgery: Analyzing the Updated Guidance

Source link : https://www.newshealth.biz/health-news/glp-1-use-prior-to-surgery-analyzing-the-updated-guidance/ Glatter is an assistant professor of emergency medicine. Papadakos is a director of critical care medicine and a professor of anesthesiology, surgery, neurology, neurosurgery, and internal medicine. Since the modern practice…

Sustained Viral Suppression in Multidrug-Resistant HIV With Lenacapavir at 3 Years

Source link : https://www.newshealth.biz/health-news/sustained-viral-suppression-in-multidrug-resistant-hiv-with-lenacapavir-at-3-years/ In 3-year data from the CAPELLA study, the subcutaneous, long-acting capsid inhibitor lenacapavir (Sunlenca) demonstrated sustained suppression with no emergence of resistance in highly treatment-experienced individuals with multidrug-resistant HIV. The findings…